Bcl-2 Family Inhibitors

Bcl-2

Bcl-xL

Bcl-W

Mcl-1

Bfl-1

Bcl-B

Bax

Bak

Bim

BNIP3

Bcl-2 Family Ligands, Degraders, Inducers, Inhibitors, Agonists, Antagonists, Activators & Modulators

Product Name	Bcl-2	Bcl-xL	Bcl-W	Mcl-1	Bfl-1	Bcl-B	Bax	Bak	Bim	BNIP3	Purity
Venetoclax	Bcl-2, Ki: 0.01 nM	Bcl-xL, Ki: 48 nM	Bcl-W, Ki: 245 nM								99.95%
Polyinosinic-polycytidylic acid	Bcl-2						Bax				99.40%
Navitoclax	Bcl-2, Ki: 1 nM	Bcl-xL, Ki: 1 nM	Bcl-W, Ki: 1 nM								99.97%
Sulforaphane							Bax				99.75%
ABT-737	Bcl-2, EC₅₀: 30.3 nM	Bcl-xL, EC₅₀: 78.7 nM	Bcl-W, EC₅₀: 197.8 nM	Mcl-1, EC₅₀: >10 μM	Bfl-1, EC₅₀: >10 μM	Bcl-B, EC₅₀: 1820 nM					99.72%
S63845				MCL1, Kd: 0.19 nM							99.94%
A-1331852	Bcl-2, Ki: 6 nM	Bcl-xL, Ki: 0.01 nM	Bcl-W, Ki: 4 nM	Mcl-1, Ki: 142 nM							99.93%
Chlorin e6	Bcl-2						Bax				98.31%
BAI1							Bax				99.89%
BT2				Mcl-1, Ki: 59 μM							99.81%
AZD-5991				Mcl-1, IC₅₀: 0.7 nM Mcl-1, Kd: 0.17 nM							99.79%
Estradiol benzoate							Bax				99.89%
A-1155463	Bcl-2, Ki: 80 nM	Bcl-xL, Ki: 0.01 nM									99.60%
Amantadine	Bcl-2						Bax				99.90%
MIK665				Mcl-1, IC₅₀: 1.81 nM							99.11%
Benzbromarone	Bcl-2										99.81%
Digitoxin	Bcl-2						Bax				99.36%
Obatoclax Mesylate	Bcl-2, Ki: 220 nM	Bcl-xL, Ki: 1-7 μM	Bcl-W, Ki: 1-7 μM	Mcl-1, Ki: 1-7 μM		Bcl-B, Ki: 1-7 μM					99.85%
Gambogic Acid	Bcl-2, IC₅₀: 1.21 μM	Bcl-xL, IC₅₀: 1.47 μM	Bcl-W, IC₅₀: 2.02 μM	Mcl-1, IC₅₀: 0.79 μM	Bfl-1, IC₅₀: 1.06 μM	Bcl-B, IC₅₀: 0.66 μM					98.79%
Poly (I:C):Kanamycin (1:1)	Bcl-2						Bax
Gossypol	Bcl-2, Ki: 0.2-0.3 mM	Bcl-xL, Ki: 0.5-0.6 μM									99.67%
Dehydrocorydaline	Bcl-2						Bax				99.77%
Bax inhibitor peptide V5							Bax				98.99%
UMI-77	Bcl-2, Ki: 23.83 μM	Bcl-xL, Ki: 32.99 μM	Bcl-W, Ki: 8.19 μM	Mcl-1, Ki: 0.49 μM	Bfl-1, Ki: 5.33 μM						99.66%
Dihydrocapsaicin	Bcl-2	Bcl-xL					Bax				99.93%
AZD4320	BCL2, IC₅₀: 17 nM (KPUM-UH1 cells)	BCLxL, IC₅₀: 17 nM (KPUM-UH1 cells)									99.66%
Hydralazine hydrochloride	Bcl-2	Bcl-xL									99.97%
WEHI-539 hydrochloride		Bcl-xL, IC₅₀: 1.1 nM									99.72%
Gossypol (acetic acid)	Bcl-2, Ki: 0.2-0.3 mM	Bcl-xL, Ki: 0.5-0.6 μM									99.75%
A-1210477	Bcl-2, Ki: 132 nM		Bcl-W, Ki: 2280 nM	Mcl-1, Ki: 0.45 nM	Bfl-1, Ki: 660 nM						99.86%
Amantadine hydrochloride	Bcl-2						Bax				≥98.0%
Carboxymethyl chitosan	Bcl-2						Bax
Lisaftoclax	Bcl-2, IC₅₀: 2 nM	Bcl-xL, IC₅₀: 5.9 nM									99.28%
AS 1411	Bcl-2										99.52%
MSN-125							Bax	Bak			99.00%
AVN-944							Bax	Bak			99.89%
Deltamethrin	Bcl-2						Bax				99.93%
Tapotoclax				Mcl-1, Ki: 0.13 nM							99.53%
Peiminine	Bcl-2										99.94%
Triclabendazole	Bcl-2						Bax				99.36%
Paris saponin VII	Bcl-2										99.96%
(R)-Sulforaphane							Bax				99.48%
BTSA1							Bax, IC₅₀: 250 nM Bax, EC₅₀: 144 nM				99.77%
PROTAC Bcl2 degrader-1	Bcl-2, DC₅₀: 3 μM Bcl-2, IC₅₀: 4.94 μM			Mcl-1, IC₅₀: 11.81 μM							99.80%
Co(III) protoporphyrin IX chloride	Bcl-2
Humanin							Bax				99.83%
TCPOBOP	Bcl-2										99.70%
PROTAC Mcl1 degrader-1	Bcl-2, IC₅₀: 0.54 μM			Mcl-1, IC₅₀: 0.78 μM							98.13%
TC11				MCL1							99.55%
(E)-Ferulic acid							Bax				99.89%
Pyraclostrobin	Bcl-2						Bax				99.91%
Bz 423							Bax	Bak			99.72%
GM-90257	Bcl-2										99.90%
Bim-IN-1									Bim		99.57%
Jaceosidin							Bax				99.51%
TW-37	Bcl-2, Ki: 290 nM	Bcl-xL, Ki: 1110 nM		Mcl-1, Ki: 260 nM							99.27%
MSN-50							Bax	Bak			98.68%
S55746	Bcl-2, Ki: 1.3 nM Bcl-2, Kd: 3.9 nM	Bcl-xL, Ki: 520 nM Bcl-xL, Kd: 186 nM									99.91%
CLZ-8				Mcl-1, Ki: 0.3 μM							99.85%
Navitoclax-piperazine		Bcl-xL									99.73%
Poly-L-lysine hydrobromide (MW 30000-70000)	Bcl-2						Bax
(R)-(-)-Gossypol	Bcl-2, Ki: 260 nM	Bcl-xL, Ki: 480 nM		Mcl-1, Ki: 170 nM							98.82%
L6H21	Bcl-2						Bax				99.19%
Sabutoclax	BCL2, IC₅₀: 0.32 μM	Bcl-xL, IC₅₀: 0.31 μM		Mcl-1, IC₅₀: 0.2 μM	Bfl-1, IC₅₀: 0.62 μM						99.80%
PROTAC Bcl-xL degrader-2		Bcl-xL, IC₅₀: 0.6 nM									98.23%
VU0661013				Mcl-1							98.45%
BMS-195614	BCL2										99.5%
SYM 2081	Bcl-2						Bax				≥98.0%
(R)-(-)-Gossypol acetic acid	Bcl-2, Ki: 260 nM	Bcl-xL, Ki: 480 nM		Mcl-1, Ki: 170 nM							98.93%
BM-1197	Bcl-2, IC₅₀: 3.5 nM	Bcl-xL, IC₅₀: 5.2 nM									99.48%
Rehmannioside A	Bcl-2										99.96%
Isolinderalactone	Bcl-2										98.79%
XZ739		Bcl-xL, DC₅₀: 2.5 nM									99.06%
HA14-1	Bcl-2, IC₅₀: 9 μM										≥98.0%
ML311				Mcl-1					Bim		98.98%
Maritoclax				Mcl-1, IC₅₀: 10.1 μM							99.97%
MCL-1/BCL-2-IN-1	Bcl-2, IC₅₀: 3.18 μM			Mcl-1, IC₅₀: 4.45 μM							99.86%
BH3I-1	Bcl-2	Bcl-xL						Bak	Bim		≥98.0%
PUMA BH3								Bak, Kd: 26 nM			98.24%
Vanillyl alcohol	Bcl-2						Bax				99.68%
(S)-Gossypol (acetic acid)	Bcl-2	Bcl-xL									98.39%
Pyridoclax				Mcl-1							99.95%
Murizatoclax				MCL1, Ki: 15 pM							98.85%
A-385358	Bcl-2, Ki: 67 nM	Bcl-xL, Ki: 0.8 nM									98.19%
BAX-IN-1							Bax				98.05%
PZ703b		Bcl-xL									98.00%
Ginsenoside Rh4							Bax				99.28%
BAM7							Bax, IC₅₀: 3.3 μM				98.53%
Aspidin BB	Bcl-2						Bax				98.08%
GL0388							Bax				98.01%
MNK8	Bcl-2										99.76%
MIM1				Mcl-1							≥98.0%
Thevetiaflavone	Bcl-2						Bax				≥98.0%
Bax activator-1							Bax				98.45%
Bfl-1-IN-2					Bfl-1, IC₅₀: 4.3 μM						99.76%
AZD-5991 (S-enantiomer)				Mcl-1, IC₅₀: 6.3 μM Mcl-1, Kd: 0.98 μM							99.83%
Destruxin B	Bcl-2										99.86%
S55746 hydrochloride	Bcl-2, Ki: 1.3 nM Bcl-2, Kd: 3.9 nM	Bcl-xL, Ki: 520 nM Bcl-xL, Kd: 186 nM									99.66%
Obatoclax	BCL2, Ki: 200 nM	Bcl-xL, Ki: 1-7 μM	Bcl-W, Ki: 1-7 μM	Mcl-1, Ki: 1-7 μM		Bcl-B, Ki: 1-7 μM					≥99.0%
Apogossypolone	Bcl-2, Ki: 35 nM	Bcl-xL, Ki: 660 nM		Mcl-1, Ki: 25 nM							98.58%
Mcl-1 inhibitor 6	Bcl-2, Kd: >10 μM Bcl2A1, Kd: >10 μM Bcl-2, Ki: 10 μM	Bcl-xL, Kd: >10 μM	Bcl-W, Kd: >10 μM	Mcl-1, Kd: 0.23 nM Mcl-1, Ki: 0.02 μM	Bfl-1, Ki: 1.57 μM						98.40%
IMB-XH1				Mcl-1							≥98.0%
(+)-Apogossypol	Bcl-2, EC₅₀: 2.8 μM	Bcl-xL, EC₅₀: 3.69 μM		Mcl-1, EC₅₀: 2.6 μM
BBR-BODIPY							Bax				98.15%
n-Butyl-β-D-fructofuranoside	Bcl-2						Bax
Anticancer agent 43							Bax				98.58%
PZ703b TFA		Bcl-xL									98.62%
Apoptosis inducer 19	Bcl-2						Bax				98.31%
Mcl1-IN-1				Mcl-1, IC₅₀: 2.4 μM							98.02%
WEHI-539		Bcl-xL, IC₅₀: 1.1 nM
Mcl1-IN-9				Mcl-1, Ki: 0.03 nM
Bcl-2-IN-2	Bcl-2, IC₅₀: 0.034 nM	Bcl-xL, IC₅₀: 43 nM
AZD-5991 Racemate				Mcl-1, IC₅₀: 3 nM
BPA-B9	Bcl-2			Mcl-1
(E)-Mcl-1 inhibitor 7				Mcl-1, Ki: <10 nM Mcl-1, IC₅₀: <500 nM
Mcl-1 inhibitor 3				Mcl-1, IC₅₀: 19 nM Mcl-1, Ki: 0.061 nM
Amantadine sulfate	Bcl-2						Bax
BM 957	Bcl-2, IC₅₀: 5.4 nM Bcl-2, Ki: 1.2 nM	Bcl-xL, IC₅₀: 6.0 nM Bcl-xL, Ki: <1 nM
Mcl-1 inhibitor 12				Mcl-1, Ki: 0.22 nM
c-MYC/BCL2 ligand 1 iodide	Bcl-2, Kd: 0.56 μM
Jaceosidin (Standard)							Bax
Bcl-2-IN-10							Bax
Bcl-2-IN-23	Bcl-2
Antitumor agent-77	Bcl-2						Bax
Bcl-2-IN-4	Bcl-2, IC₅₀: 1.5 nM	Bcl-xL, IC₅₀: 411 nM
eIF4E/eIF4G PPI-IN-1	Bcl-2
Lobetyol	Bcl-2						Bax
FMP							Bax
8α-Tigloyloxyhirsutinolide 13-O-acetate	Bcl-2	Bcl-xL		Mcl-1
PROTAC Bcl-xL degrader-3		Bcl-xL
A09-003				Mcl-1
YVPGP		Bcl-xL					Bax
G721-0282	Bcl-2
TRP-601	Bcl-2
WR-S-462	Bcl-2	BCLxL
Bcl-2/Mcl-1-IN-2	Bcl-2, Ki: 4.70 μM			Mcl-1, Ki: 0.88 μM
BRD4 Inhibitor-15	Bcl-2						Bax
TFSeB	Bcl-2						Bax
Antitumor agent-78	Bcl-2						Bax
EGFR/BRAFV600E-IN-2	Bcl-2						Bax
JNJ-4355				Mcl-1, Ki: 18 pM
BM-1074	Bcl-2, IC₅₀: 1.8 nM	Bcl-xL, IC₅₀: 6.9 nM
SMBA1							Bax, Ki: 43.3 nM
BCL-XL-IN-3		BCLxL, Ki: <0.01 nM
EMT inhibitor-3	Bcl-2						Bax
Apoptotic agent-2	Bcl-2						Bax
CT20p							Bax
Bcl-2-IN-9	Bcl-2, IC₅₀: 2.9 μM (^[1])
Bcl-2-IN-11	Bcl-2, IC₅₀: 0.9 nM	Bcl-xL, IC₅₀: >1000 nM
PI3K-IN-58	Bcl-2	Bcl-xL					Bax
Bcl-2/Mcl-1-IN-4	Bcl-2, Ki: 0.49 μM			Mcl-1, Ki: 0.51 μM
LSD1-IN-26	Bcl-2
Topoisomerase I inhibitor 17	Bcl-2						Bax
Bcl-2/Mcl-1-IN-1	Bcl-2, Ki: 4.53 μM			Mcl-1, Ki: 1.19 μM
Anticancer agent 64	Bcl-2						Bax
Bcl-2-IN-5	Bcl-2, IC₅₀: 0.12 nM
Mcl-1 inhibitor 13				Mcl-1, Ki: 8.2 nM
HSP70-IN-6									Bim
CYD-4-61							Bax
Bcl-2-IN-6	Bcl-2						Bax
Bcl-2/Mcl-1-IN-3	Bcl-2, Ki: 0.23 μM	Bcl-xL, Ki: 15 μM		Mcl-1, Ki: 0.14 μM
YX0798				Mcl-1
Bcl-2-IN-7	Bcl-2						Bax
PZ671		Bcl-xL
4-Hydroxyresveratrol							Bax
PROTAC Bcl-xL degrader-1		Bcl-xL
Anticancer agent 201	Bcl-2	Bcl-xL
Astin B	Bcl-2						Bax
GQN-B37-E				Mcl-1, Ki: 0.6 μM
BDA-366	Bcl-2, Ki: 3.3 nM
β-Eleostearic acid	Bcl-2
EGFR-IN-109	Bcl-2						Bax
CDK1/2/4-IN-1	Bcl-2						Bax
Dehydrobruceine B	Bcl-2	Bcl-xL					Bax
Apoptotic agent-3	Bcl-2						Bax
EGFR-IN-134	Bcl-2						Bax
YC137	Bcl-2, Ki: 1.3 μM	Bcl-xL, Ki: >100 μM
PZ703b hydrochloride		Bcl-xL									99.18%
Topo I/II-IN-2	Bcl-2						Bax
anti-TNBC agent-3	Bcl-2
PI3K/mTOR-IN-17	Bcl-2						Bax
AF151	Bcl-2			Mcl-1
Anticancer agent 65	Bcl-2						Bax
Anticancer agent 63	Bcl-2
Furowanin A				Mcl-1
PROTAC PI3K/110β degrader-2	Bcl-2						Bax
RU28362										BNIP3
PUMA BH3 TFA								Bak, Kd: 26 nM
Spicamycin	Bcl-2
VEGFR-2/AKT-IN-2	Bcl-2
Bcl-2-IN-3	Bcl-2
(-)BI97D6	Bcl-2, IC₅₀: 0.031 μM	Bcl-xL, IC₅₀: 0.076 μM		Mcl-1, IC₅₀: 0.025 μM
Bax agonist 1							Bax, Ki: 57.2 nM
Thaspine acetate							Bax	Bak
MLS-0053105	Bcl-2/F-Bim, IC₅₀: 12.5 μM	Bcl-XL/F-Bim, IC₅₀: 50 μM	Bcl-W/F-Bim, IC₅₀: 12.5 μM		Bfl-1/F-Bid, IC₅₀: 0.4 μM
Myrothecine A							Bax
Vanillyl alcohol (Standard)	Bcl-2						Bax
YCW-E11	Bcl-2			Mcl-1
Mcl1-IN-15				Mcl-1, IC₅₀: 8.73 μM
TM-233				Mcl-1
Bak BH3		Bcl-xL

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